Fundamental Cell Biology of Membrane Excitability

Dr. Nerbonne is leading an effort to understand the macromolecular complexes of voltage-gated K channels using proteomic approaches for isolating and analyzing membrane proteins.

Dr. Nichols is leading a collaboration with Blanche Schwappach at Manchester University in the UK to understand the trafficking of diabetes-causing K-ATP channel subunits using proteomic approaches. Image shows Western blots of isolated K-ATP proteins from wild type and knockout animals.