Mecham, Robert

Alumni Endowed Professor and Interim Head, Cell Biology & Physiology, Professor of Medicine, Pediatrics and Bioengineering

The protein elastin is responsible for the elastic properties of the lung and the blood vessels. Several genetic diseases (Marfan Syndrome, Williams Syndrome and supravalvular aortic stenosis) and acquired diseases (hypertension, atherosclerosis etc.) are linked to alterations/mutations in genes for elastic fiber proteins.  Our research focuses on learning how elastin influences lung and blood vessel function and how mutations in elastin lead to disease.