Kefalov, Vladimir J.

Associate Professor of Ophthalmology and Visual Sciences

We are interested in the function of mammalian rod and cone photoreceptors. These sensory neurons use a prototypical G-protein signaling cascade to convert light into electric signal as the first step in visual perception. Our studies involve the use a battery of state-of-the-art tools, from single-cell and isolated retina electrophysiological recordings, to in vivo electroretinogram and behavior experiments with wild type and genetically modified mice. We are also investigating the mechanisms of neurodegeneration in the retina and are working on developing pharmacological and gene-therapy tools for preventing photoreceptor cell death.