Current Projects

  • Call for Applications for Pilot and Feasibility Awards

    Center for the Investigation of Membrane Excitability Diseases Home Pilot Grant Program CIMED sponsors a pilot project program. Center members are eligible to apply for two year grants of up to $25,000/year to be used for acquisition of new preliminary data for interdisciplinary studies related to the Center’s mission. New components for 2018 application • […]

  • Applications for Pilot and Feasibility Awards

    Center for the Investigation of Membrane Excitability Diseases Home Pilot Grant Program CIMED sponsors a pilot project program. Center members are eligible to apply for two year grants of up to $25,000/year to be used for acquisition of new preliminary data for interdisciplinary studies related to the Center’s mission. New components for 2017 application • […]

  • Applications for Pilot and Feasibility Awards

    Center for the Investigation of Membrane Excitability Diseases Home Pilot Grant Program CIMED sponsors a pilot project program. Center members are eligible to apply for two year grants of up to $25,000/year to be used for acquisition of new preliminary data for interdisciplinary studies related to the Center’s mission. New components for 2017 application • […]

  • CIMED has awarded two Pilot and Feasibility grants for 2015

    Peng Yuan, Ph.D. Assistant Professor, Cell Biology & Physiology “Molecular Mechanisms of Copper Homeostasis” Copper is a trace element of vital importance in human physiology, with many enzymes using copper as an essential cofactor to perform their specific work. Copper homeostasis is fundamental to many critical physiological processes including liver function and the development of […]

  • Fundamental Cell Biology of Membrane Excitability

    Jeanne Nerbonne, Ph.D.

    Dr. Nerbonne is leading efforts to identify the voltage-gated K+ and Na+ channels expressed in mammalian cardiac myocytes and central neuronss, to define the physiological roles and the molecular determinants of these channels, and to delineate the molecular, cellular and systemic mechanisms involved in the regulation of the expression and functioning of these channels.

  • Micro Grant Program

    Micro Grant Program The CIMED Live Cell Imaging Facility (http://cimed.wustl.edu/downloads/LiveCellImagingFacility.pdf) has been developed to provide and further develop state-of-the-art imaging platforms for live cell measurements. CIMED is making available micro ($1000) grants in FY2014 to encourage and facilitate use of the LCIF. General Applications (1 page maximum) together with applicant’s CV, should be submitted to […]

  • “Electrophysiology of long-term culture of adult human myocardium”

    Igor Efimov, Ph.D.

    Genetic manipulation and regulation of ion channel expression has been studied thoroughly in a large variety of animal models and in cell culture. However, the clinical translation of the results of these studies has been hampered by significant differences in genetics, cell and tissue physiology between various animal models, on the one hand, and human patients, on the […]

  • “CLCA1 Regulation of Calcium-Activated Chloride Channels in Chronic Lung Diseases”

    Thomas Brett, Ph.D.

    Calcium-activated chloride channels (CaCCs) play a central role in airway health and disease. In homeostasis, they contribute to normal mucus salinity and hydration. However, overactivation of CaCCs in the airway has been linked to mucus cell metaplasia (MCM), and consequent excess mucus production in chronic airway diseases. The secreted protein CLCA1 is a potent modulator of CaCCs and […]

  • “Sulfonylureas in Type 1 Diabetes”

    Bess Marshall, M.D.

    Sulfonylureas are used to re-establish glucose mediated insulin secretion in individuals with neonatal diabetes. The mechanisms by which glucose mediated insulin secretion can be altered as a result of genetic mutations has expanded exponentially by studying the genetic defects of individuals with neonatal diabetes and hyperinsulinism. We propose a pilot study to evaluate sulfonylurea response in Type 1 […]

  • Translation approaches to Excitability Disorders

    Colin Nichols, Ph.D.

    A major goal of CIMED is to integrate basic science advances with clinical research and practice. In collaboration with Bess Marshall and Neil White (Pediatrics), and with Ken Polonsky (Medicine), Dr. Nichols is leading efforts to translate the findings from animal models of KATP-induced diabetes (above) to understanding and therapy of neonatal and type 2 […]