Center Members

  • Akk, Gustav

    Ph.D.
    Assistant Professor of Anesthesiology

    Lab Website

    My lab is interested in how ligand-gated ion channel work. We focus on the GABAA and nicotinic acetylcholine receptors.

  • Ben-Shahar, Yehuda

    Ph.D.
    Assistant Professor of Biology

    Lab Website

    One of the major areas of research in my group is to study the neurobiology of Degenerin/epithelial sodium channels. These non-voltage gated ion channels play diverse physiological roles in epithelial and neuronal tissues. My group is focusing on studies of these channels in the fruit fly, Drosophila melanogaster.  

  • Blumer, Kendall J.

    Ph.D.
    Professor of Cell Biology and Physiology

    Lab Website

    Description of Research: Research in the Blumer laboratory aims to identify novel mechanisms of G protein-coupled receptor (GPCR) signaling and to elucidate functions of these mechanisms in development, physiology and disease.  Because various ion channels are targets of GPCR signaling, elucidating their regulation by these novel mechanisms is a major objective.  Biochemical, pharmacological, molecular and […]

  • Brett, Thomas

    Ph.D.
    Assistant Professor of Internal Medicine

    Lab Website

    Description of Research: Chloride channels and their regulators play key roles in airways biology, both in homeostasis and disease states. The CLCA proteins are key regulators of calcium-activated chloride channels (CaCCs) in mucosal tissues and play integral roles in chronic inflammatory airway diseases such as asthma and COPD. We are interested in understanding the structural, […]

  • Bruchas, Michael R.

    Ph.D.
    Assistant Professor of Anesthesiology and Anatomy/Neurobiology

    Lab Website

    Our laboratory investigates the interactions between stress neurobiology and GPCRs in neural circuits.  My lab’s current projects include exploring the role of neuropeptide neural circuits in stress-induced behaviors, developing novel optogenetic tools and engineering approaches, and my laboratory is actively pursuing projects related to dissecting circuits, signaling, and the neurophysiological mechanisms underlying depression, anxiety, pain and […]

  • Cao, Yu-Qing

    Ph.D.
    Assistant Professor of Anesthesiology

    Lab Website

    We are interested in the contribution of voltage-gated calcium channels to synaptic transmission and migraine pathophysiology

  • CHOI, Kyunghee

    Ph.D.
    Associate Professor of Pathology and Immunology

    We investigate molecular mechanisms involved in hematopoietic and endothelial cell lineage specification. We focus on transcription factors and their target genes in the establishment of the hematopoietic and vascular systems. One of the objectives is to monitor key transcription factor activities and cell differentiation process through live cell imaging with a goal to further our […]

  • Corbo, Joseph

    M.D., Ph.D.
    Associate Professor of Pathology & Immunology

    Lab Website

    We hypothesize that the majority of functional non-coding variants related to cardiac arrhythmias fall within cardiac cis-regulatory elements (CREs; i.e., enhancers/promoters), and exert their effects by altering the expression level of genes encoding cardiac ion channels or their regulators.

  • Cui, Jianmin

    Ph.D.
    The Spencer T. Olin Professor of Biomedical Engineering

    Lab Website

    Professor Cui’s research investigates potassium (K+) ion channel structure-function relationships in normal physiology and disease, specifically heart contraction and neural activities.

  • England, Sarah K.

    Ph.D.
    Alan A and Edith L Wolff Professor of Medicine

    Lab Website

    Description of Research: Professor England’s basic science research focuses on the molecular mechanisms underlying uterine function during pregnancy. Her research has been investigating the roles of potassium channels in regulating smooth muscle excitability, with an emphasis on myometrial smooth muscle.

  • Evers, Alex S.

    M.D.
    Henry E. Mallinckrodt Professor and Chairman of Anesthesiology

    Lab Website

    Description of Research: My laboratory focuses on the protein chemistry of GABAA receptors to identify and characterize drug binding sites, sequence variants and post-translational modifications as well as to define the protein complexes in which GABAA receptors reside in vivo. A variety of biochemical and molecular biological approaches are applied to these problems, with particular […]

  • Grange, Dorothy K.

    M.D.
    Professor of Pediatrics

    Lab Website

    Description of Research: I am involved in the diagnosis and management of patients with a wide variety of genetic conditions, including single disorders, chromosome abnormalities, inborn errors of metabolism. I have developed a particular interest in Cantu syndrome, which is a rare autosomal dominant disorder  associated with cardiovascular abnormalities, bone dysplasia and hirsutism. Cantu syndrome […]

  • Gross, Richard W.

    M.D., Ph.D.
    Professor of Medicine, Chemistry and Developmental Biology

    Lab Website

    Description of Research: Our research examines the roles of alterations in membrane structure dynamics and signaling on the biologic functions of cellular membranes.

  • Guilak, Farshid

    Ph.D.
    Professor of Orthopaedic Surgery

    Lab Website

    A major portion of my research program is focused on the role of ion channels in mechanotransduction in musculoskeletal tissues, particularly TRPV4 and Piezo channels.

  • Halabi, Carmen

    M.D., Ph.D.
    Instructor in Pediatrics

    “Our research focuses on understanding the role of extracellular matrix proteins in cardiovascular development and disease.  Elastic fibers constitute the majority of large arteries’ extracellular matrix and allow these arteries to store energy during systole and release it during diastole.  We utilize mouse models carrying disease-causing mutations in elastic fiber-associated genes to gain insight into […]

  • Halcomb, Eliza

    M.D.
    Assistant Professor of Emergency Medicine

    Lab Website

    Description of Research: My research interest includes the role of the KATP channel in the maintenance of vascular tone.

  • Haswell, Elizabeth

    Ph.D.
    Associate Professor of Biology

    Lab Website

    My group is currently studying the structure, function, regulation, and evolution of a family of mechanosensitive ion channels related to the bacterial channel MscS, using live-imaging, single-channel patch clamp electrophysiology, and complementary biochemical and molecular genetic approaches. We are also engaged in functional and genetic screens designed to identify novel mechanosensory proteins, and in the development of new tools for the non-invasive analysis of […]

  • Hou, Jianghui

    Ph.D.
    Associate Professor of Medicine

    Lab Website

    Description of Research: I am studying the biophysical and biochemical nature of the paracellular channels in the kidney and their pathogenic role underlying renal diseases.

  • Hruz, Paul

    Ph.D., M.D.
    Associate Professor of Pediatrics, Pediatric Endocrinology

    Lab Website

    Dr. Hruz’s research interests include intermediary carbohydrate metabolism, glucose transporter structure and function and mechanism of insulin action. A primary focus has been the elucidation of molecular mechanisms leading to altered glucose homeostasis during the treatment of HIV infection.  The laboratory has discovered that HIV protease inhibitors selectively and reversibly inhibit the GLUT4 facilitative glucose […]

  • Hu, Hongzhen

    Ph.D.
    Assistant Professor of Anesthesiology

    Lab Website

    Research in our laboratory aims to  understand the cellular and molecular basis of pain and itch. We take a multidisciplinary approach to investigate the role of membrane receptors and ion channels, especially the transient receptor potential (TRP) channels, in itch and pain transduction under normal and pathological conditions.

  • Huettner, James

    Ph.D.
    Professor of Cell Biology and Physiology

    Lab Website

    Description of Research: Research Interests: Glutamate receptors, synaptic transmission and stem cell differentiation.

  • Hyrc, Krzysztof (Kris)

    Ph.D.
    Assistant Professor of Neurology

    My research is focused on the role of calcium ions in regulating cellular processes. I am particularly interested in theoretical and practical aspects of measuring intracellular free calcium concentrations with the use of fluorescent calcium indicators.  

  • Kefalov, Vladimir J.

    Ph.D.
    Associate Professor of Ophthalmology and Visual Sciences

    Lab Website

    We are interested in the function of mammalian rod and cone photoreceptors. These sensory neurons use a prototypical G-protein signaling cascade to convert light into electric signal as the first step in visual perception. Our studies involve the use a battery of state-of-the-art tools, from single-cell and isolated retina electrophysiological recordings, to in vivo electroretinogram […]

  • Klyachko, Vitaly A.

    Ph.D., Biophysics
    Associate Professor of Cell Biology and Physiology and Biomedical Engineering

    Lab Website

    Dr. Klyachko’s research is focused on synaptic function and plasticity with the goal of understanding how neural circuits analyze information in the brain.

  • Lingle, Christopher J.

    Ph.D.
    Professor of Anesthesiology, Anatomy and Neuroscience

    Lab Website

    Description of Research: Using a combination of molecular, biophysical, genetic, and behavioral methods, we seek to understand the normal physiological roles of large-conductance K+ permeant channels that are regulated by cytosolic ions (Ca2+, Na+).

  • Mann, Douglas

    M.D.
    Lewin Professor and Chief, Cardiovascular Division Washington University School of Medicine

    Lab Website

    Description of Research: Dr. Mann’s primary area of research is in the molecular and cellular basis of heart failure, with a particular emphasis on the role of inflammatory mediators in disease progression in the failing heart.

  • Marshall, Bess A.

    M.D.
    Associate Professor of Pediatrics, Division of Endocrinology & Diabetes; Associate Director, Pediatric Office of Faculty Development, Associate Professor of Cell Biology and Physiology

    Lab Website

    Description of Research: My research interests include diabetes and insulin sensitivity in children, neonatal and monogenic diabetes, and Wolfram syndrome.

  • Mecham, Robert

    Ph.D.
    Alumni Endowed Professor and Interim Head, Cell Biology & Physiology, Professor of Medicine, Pediatrics and Bioengineering

    Lab Website

    The protein elastin is responsible for the elastic properties of the lung and the blood vessels. Several genetic diseases (Marfan Syndrome, Williams Syndrome and supravalvular aortic stenosis) and acquired diseases (hypertension, atherosclerosis etc.) are linked to alterations/mutations in genes for elastic fiber proteins.  Our research focuses on learning how elastin influences lung and blood vessel […]

  • Mercer, Robert

    Ph.D.
    Professor of Cell Biology and Physiology

    Lab Website

    Description of Research: Molecular and cell biology of ion pumps and transporters in plasma membrane; cell polarity

  • Mohapatra, DP

    Ph.D.
    Associate Professor of Anesthesiology

    Lab Website

    The major focus of our research group is to understand the diverse mechanisms of ion channel modulations in mammalian sensory neurons that lead to enhanced excitation of these neurons under acute and chronic pain conditions associated with metastatic bone cancers, injury/inflammation and obesity.  In addition, our laboratory is also investigating the role of voltage-gated K? channels in […]

  • Nerbonne, Jeanne M.

    Ph.D.
    CIMED Co-Director
    Alumni Endowed Professor of Molecular Biology and Pharmacology and Internal Medicine

    Lab Website

    Research in this laboratory explores the molecular, cellular and systemic mechanisms involved in the dynamic regulation of neuronal and cardiac membrane excitability.

  • Nichols, Colin G.

    Ph.D.
    CIMED Director
    Carl Cori Professor, Professor of Cell Biology and Physiology

    Lab Website

    Research in my laboratory is focused on the biology of ion channels, with emphasis on the molecular basis of potassium channel activity, and the role of potassium channels in physiology and disease. Using various molecular biological and biophysical approaches, we are developing a detailed understanding of the structural basis of channel activity. Using gene manipulation approaches, we are developing understanding of the role of potassium channels in disease processes including diabetes, cardiac arrhythmia and epilepsy.

  • Payton, Jacqueline

    M.D., Ph.D.
    Assistant Professor

    Lab Website

    The Payton Lab is a “damp” lab that integrates -omics discovery via bioinformatic analysis of large datasets with cellular and molecular experimental models to elucidate novel regulatory mechanisms. Our research focuses on the roles of non-coding regulatory elements in promoting cellular transformation and cancer, specifically in Non-Hodgkin Lymphoma.

  • PISTON, David

    Ph.D.
    Edward J. Mallinckrodt Jr. Professor and Head of the Department of Cell Biology & Physiology

    Lab Website

    Our diverse research group focuses on the understanding the molecular mechanisms that underlie hormone secretion from islets of Langerhans in the pancreas. Driven by this biomedical focus, the lab develops, optimizes, and applies novel fluorescence microscopies and probes, largely based on the Green Fluorescent Protein and its relatives. The lab combines these new approaches for […]

  • Randolph, Gwendalyn

    Ph.D.
    Professor Department of Pathology & Immunology

    GRandolph@path.wustl.edu

    Lab Website

    My laboratory’s research integrates the study of monocytes, macrophages, and dendritic cells with vascular and lymphatic vessel biology. We are driven to understand how the regulation of lymphatic transport is linked to chronic inflammatory disease.

  • Remedi, Maria S.

    Ph.D.
    Assistant Professor of Medicine (PEFA)

    Lab Website

    The main goal of my research is to understand the role and consequences of altered channel excitability in pancreas and brain, since these channels are a critical link between metabolism and hormone secretion in these tissues.

  • Rentschler, Stacey

    M.D., Ph.D.
    Assistant Professor of Medicine & Developmental Biology

    We will seek to better understand the mechanisms by which Notch regulates cardiac conduction in normal and disease states

  • Rudy, Yoram

    Ph.D., F.A.H.A.
    The Fred Saigh Distinguished Professor of Engineering, Director of the Cardiac Bioelectricity and Arrhythmia Center

    Lab Website

    Description of Research: Our Research aims at understanding the mechanisms that underlie normal and abnormal rhythms of the heart at various levels, from the molecular (ion channel) and cellular to the whole heart. We are also developing a novel noninvasive imaging modality (Electrocardiographic Imaging, ECGI) for the diagnosis and guided therapy of cardiac arrhythmias.

  • Salkoff, Lawrence B.

    Ph.D.
    Professor of Anatomy and Neurobiology, Genetics

    Lab Website

    Description of Research: Our laboratory studies potassium channels which are key elements which control and shape electrical activity in the brain, heart, and other excitable tissues. These channels are major determinants of behavior and higher brain function. The potassium channels we study are involved in human disease (e.g. epilepsy, cardiac arrhythmia), basic physiology (e.g. control […]

  • Schlesinger, Paul

    M.D., Ph.D.
    Associate Professor of Cell Biology and Physiology

    Lab Website

    Description of Research: My research has focused on intracellular transport of ions, including protons, their influence on the physiology of cells. Over the years this has included the acidification of intracellular vesicles, chloroquine transport and resistant malaria parasites, intracellular mycobacteria, bone resorption, intracellular chloride channels, membrane channels and pores formed by Bcl-2 family proteins in […]

  • Silva, Jennifer

    M.D.
    Assistant Professor of Pediatrics

    Lab Website

    Description of Research: My research interests include sudden cardiac death, inherited channelopathies, efficacy of cardiac resynchronization therapy in pediatric heart failure patients and clinical applications of noninvasive electrocardiographic imaging.

  • Silva, Jonathan

    Ph.D.
    Assistant Professor of Biomedical Engineering

    Lab Website

    Description of Research: Our group studies how perturbations to molecular motions propagate across time and spatial scales to affect the heart rhythm.  We’re currently focused on the cardiac sodium channel, which initiates cardiac excitation and contraction. By studying the sodium channel using simultaneous fluorescence and ionic current recording, the effect of genetic mutations and drugs that […]

  • Steinbach, Joe Henry

    Ph.D.
    Professor of Anesthesiology

    Lab Website

    Description of Research: Many cells respond to extracellular molecules by means of chemically activated ion channels in their cell membrane. In the nervous system transmitter-activated channels underlie rapid synaptic transmission. The goal of work in my lab is to determine how transmitter-gated channels are activated and how cells control the way in which their chemically […]

  • Vig, Monika

    Ph.D.
    Assistant Professor of Pathology and Immunology

    Lab Website

    Research Abstract: We study signaling mechanisms in developing and mature lymphocytes. In particular, we are interested in understanding the origin and outcome of localized intracellular calcium fluxes. Calcium ions are important ‘second messengers’ that regulate nearly every cellular process such as gene expression, secretion, migration, cell death and metabolism. In most cells, cross-linking of tyrosine […]

  • Yang, Lan

    Ph.D.
    Assistant Professor of Electrical and Systems Engineering

    Lab Website

    Description of Research: Microsystems for detecting biomolecules can play important roles in biomedical research, clinical diagnosis, food safety, homeland security and pharmaceutical test. The research focus of my research group at Washington University is to investigate and develop new optical sensing techniques based on nanophotonic devices.

  • Yuan, Peng

    Ph.D.
    Assistant Professor of Cell Biology and Physiology

    Lab Website

    RESEARCH DESCRIPTION: My laboratory is interested in understanding the molecular mechanisms of ion channels and transporters that play essential roles in human physiology and disease. How do channels and transporters recognize their specific substrate ions? How do they respond to various stimuli including chemical ligand, temperature, membrane voltage, and mechanical force? How do they interact […]

  • Zipfel, Gregory J.

    M.D.
    Associate Professor of Neurosurgery and Neurology

    Lab Website

    Description of Research: Our laboratory has two main interests: 1) Examining the pathophysiologic effects of amyloid-? peptide on cerebrovascular function, and determining how such effects contribute to diseases including ischemic stroke, cerebral amyloid angiopathy, and Alzheimer’s Disease; and 2) Exploring the molecular basis and developing novel therapeutics for subarachnoid hemorrhage-induced cerebral vasospasm – in particular, […]